Beilstein J. Nanotechnol.2021,12, 786–797, doi:10.3762/bjnano.12.62
possible combination of stem cells and nanotechnology in the treatment of diseases. This study aims to investigate the in vitro effect of silver nanoparticles (Ag-NPs) on the cardiomyogenicdifferentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs) through detection of cardiac markers. For
this purpose, MSCs were isolated from bone marrow resident and differentiated to the cardiac cells using a dedicated medium with Ag-NPs. Also, the cardiomyogenicdifferentiation of BM-MSCs was confirmed using immunocytochemistry. Then, real-time PCR and western blotting assay were used for measuring
; cardiomyogenicdifferentiation; silver nanoparticles; telomere length; Wnt3/β-catenin signaling pathway; Introduction
Cardiac disorders that eventually lead to heart failure cause an increased loss of cardiac cells. There is strong evidence that the progression of heart failure is associated with reduction in
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Figure 1:
Morphology of BM-MSCs; (A) Fibroblast-like morphology of cells that appear 24 h after cell seeding ...